DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development
نویسندگان
چکیده
منابع مشابه
Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney.
During kidney development and in response to inductive signals, the metanephric mesenchyme aggregates, becomes polarized, and generates much of the epithelia of the nephron. As such, the metanephric mesenchyme is a renal progenitor cell population that must be replenished as epithelial derivatives are continuously generated. The molecular mechanisms that maintain the undifferentiated state of t...
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New nephron formation (nephrogenesis) ceases in mammals around birth and is completely absent in adults. In contrast, postembryonic nephrogenesis is well documented in the mesonephric kidneys of fishes and amphibians. The transient mesonephros in reptiles (including birds) and mammals is replaced by the metanephros during embryogenesis. Thus, one may speculate that postembryonic nephrogenesis i...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2019
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2018070687